Fort Myers and the surrounding metropolitan area are home to some of the foremost attractions in the entirety of Florida. There are historical sights, beautiful beaches, cultural sites, and a sampling of everything that makes Florida a popular vacation destination. Guests of vacation rentals and homes in Fort Myers can sunbathe, swim, or dive in the beautiful waters off of Sanibel and Fort Myers while enjoying the legendary weather of the Sunshine State. The ecological offerings of the Fort Myers are quite diverse, ranging from manatees and dolphins to mangrove forests and flocks of birds.

Another popular activity is shoreline fishing, although there are many companies which charter trips to deep sea spots as well. Kayaking is a popular activity, and there are also nature walks, biking trails, and outdoor festivals. The Bailey-Matthews Shell Museum hosts numerous examples of the kinds of shells and sea fossils that can be found on Ft. Myers Beaches, while the white sand beaches of the area provide plentiful opportunities for visitors to hone their skills at beachcombing. The historic Burroughs Home is yet another popular attraction, and the Boston Red Sox have spring training in Fort Myers. There are also day safaris, museums, wineries, art galleries, and even wildlife preserves.